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Medical University of South Carolina UNIV - Staff Scientist I - Surgery: Transplant Surgery in Charleston, South Carolina

FLSA: Salaried

Job Summary: MUSC is offering a unique position in the Bioengineering Core of the Transplant Research and Immunobiology Institute. We are seeking a Staff-Scientist Bioengineer to function as an independent integral member of a team of scientists, engineers and clinicians to create an end-to-end clinical translation pipeline for bio-engineered tissue. These regenerative treatments are targeted at an unmet medical need in cell and tissue transplantation for vision restoration. This position will be in collaboration with the Start Up company Pandorum Technologies, PVT. The bioengineer is expected to lead a team in development of novel biomaterials for application specific clinical indications in transplant. They will perform and supervise in vitro materials characterization including mechanical characterization and optimization. The successful candidate will be expected to conduct and supervise in vivo animal model efficacy studies in a cGMP clean cell environment. These studies and data are to be directly translatable to human trials.

Payscale Salary Range: UNIV-Band 6: $40,759.00 - $58,086.00 - $75,413.00 (min - mid - max)

Job Duties:

  • 25% - Material Characterization: Materials characterization will include but is not limited to H-NMR, FT-IR, Raman spectroscopy, HPLC-Mass spectrometry, dynamic light scattering, scanning electron microscopy, mechanical testing, rheometric testing and other hydrogel/biomaterials characterization as needed. - (Essential)

  • 25% - Cell Studies: In vitro cell culture studies will include evaluation of cell material interaction in terms of but not limited to: Cell viability, proliferation, adhesion and spreading assays and immunofluorescence staining for biomarkers such as: CSSC - CD73, CD90 Keratocan, ALDH3A1, alpha SMA, Collagen type-1, Collagen type I, Keratocan, Lumican, Decorin, and Human growth factor,HGF. - (Essential)

  • 25% - Bioreator Studies: The successful candidate will be expected to fabricate and operate Corneal perfusion chamber bioreactors to mature and develop the tissues. Bioreactor study characterizations include but are not limited to: Optical coherence tomography, Densitometry Light and confocal microscopic evaluation of engineered tissues. - (Essential)

  • 25% - Animal Studies: The successful candidate will participate in animal studies using but not limited to New Zealand white rabbits. These studies will be designed to characterize toxicity and efficacy for vision restoration using the engineered tissues. Data from these studies must be such that it can be included in regulatory IND and NDA data packages for filing with the Food and Drug Administration. - (Essential)

Minimum Experience and Training Requirements: A PhD, MD or equivalent with two years post-doctorate experience.

Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 30 lbs., unassisted. (Frequent) Ability to lift objects, up to 30 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 30 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 50 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 30 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Must be ambidextrous. Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent)